Role of a high centrality residue in protein dynamics and thermal stability

Vitor Medeiros Almeida,Apala Chaudhuri,Marcus Vinicius Cangussu Cardoso,Bruno Yasui Matsuyama,Gláucio Monteiro Ferreira,Gustavo Henrique Goulart Trossini,Roberto Kopke Salinas,J Patrick Loria,Sandro Roberto Marana

Journal of Structural Biology（2021）

引用 1|浏览17

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摘要

•Mutation Y182A disperses a high centrality residue set spreading over the HisF structure.•This mutant HisF shows less mutual influence and covariant motions between residues.•Heat distribution over this mutant HisF changes resulting in lower thermal stability.

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关键词

RIN,L,C,Ec,HisFwt,kden,IPTG

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