A light-activatable photosensitizer for photodynamic therapy based on a diarylethene derivative.

Jian Zhang,Ran Zhang,Kaiqiang Liu,Yong Li,Xu Wang,Xilei Xie,Xiaoyun Jiao,Bo Tang

Chemical communications (Cambridge, England)（2021）

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摘要

Herein, a light-activatable photosensitizer based on a diarylethene derivative, DAE-TPE, was developed for photodynamic therapy. Upon UV exposure, the "opened" form (OF) of DAE-TPE NPs was converted to the "closed" form (CF), and photosensitization was activated. The CF of DAE-TPE NPs exhibited sufficient photodynamic therapy effects upon HeLa cells.

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