Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm
JACC: Case Reports(2021)
摘要
Coronary spasm is a frequent cause of angina despite unobstructed coronary arteries, and symptom control with recommended drugs is limited. We report the case of a 77-year-old woman who had refractory angina despite conventional antianginal treatment. Repurposing riociguat, a soluble guanylate cyclase stimulator, resulted in improvement of symptoms and prevention of spasm. (Level of Difficulty: Intermediate.)
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关键词
acetylcholine testing,coronary artery spasm,drug repurposing,individual treatment trial,microvascular dysfunction,riociguat,soluble guanylate cyclase
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