Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging For The Analysis Of Microvascular Permeability In Peritumor Brain Edema Of Fibrous Meningiomas

Introduction: This study aims to analyze the permeability of intra- and peri-meningiomas regions and compare the microvascular permeability between peritumoral brain edema (PTBE) and non-PTBE using DCE-MRI. Methods: This was a retrospective of patients with meningioma who underwent surgery. The patients were grouped as PTBE and non-PTBE. The DCE-MRI quantitative parameters, including volume transfer constant (K-trans), rate constant (K-ep), extracellular volume (V-e), and mean plasma volume (V-p), obtained using the extended Tofts-Kety 2-compartment model. Logistic regression analysis was conducted to explore the risk factor of PTBE. Results: Sixty-three patients, diagnosed as fibrous meningioma, were included in this study. They were 17 males and 46 females, aged from 32 to 88 years old. K-ep and V-p were significantly lower in patients with PTBE compared with those without (K-ep: 0.1852 +/- 0.0369 vs. 0.5087 +/- 0.1590, p = 0.010; V-p: 0.0090 +/- 0.0020 vs. 0.0521 +/- 0.0262, p = 0.007), while there were no differences regarding K-trans and V-e (both p > 0.05). The multivariable analysis showed that tumor size >= 10 cm(3) (OR = 4.457, 95% CI: 1.322-15.031, p = 0.016) and V-p (OR = 0.572, 95%CI: 0.333-0.981, p = 0.044) were independently associated with PTBE in patients with meningiomas. Conclusion: DCE-magnetic resonance imaging center dot Meningioma center dot Blood vessel MRI can be used to quantify the microvascular permeability of PTBE in patients with meningioma.