TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial

Rohit Loomba,Rizwana Mohseni,K Jean Lucas,Julio A Gutierrez,Robert G Perry,James F Trotter,Robert S Rahimi,Stephen A Harrison,Veeral Ajmera,Jeffrey D Wayne,Marie O'Farrell,William McCulloch,Katharine Grimmer,Mary Rinella,Vincent Wai-Sun Wong,Vlad Ratziu,Gregory J Gores,Brent A Neuschwander-Tetri,George Kemble

Gastroenterology（2021）

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摘要

TVB-2640, an inhibitor of the fatty acid synthase enzyme, reduces excess fat in the liver of patients with nonalcoholic steatohepatitis and, by analyzing changes in their blood samples, may improve their inflammation, metabolic, and fibrosis levels.

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Palmitate,PRO-C3

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