The dysfunction of parvalbumin interneurons mediated by microglia contributes to cognitive impairment induced by lipopolysaccharide challenge

Meng Mao,Zhenhui Zhou,Menghan Sun,Chaoran Wang, Jie Sun

Neuroscience Letters（2021）

引用 8|浏览1

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摘要

•LPS induces hippocampus-dependent memory and working memory impairment.•LPS induces decreased PV expression and perisomatic boutons in the hippocampus.•Inhibition of microglial activation reverses the PV expression and cognitive damage.

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关键词

Cognitive impairment,Parvalbumin,Microglia,LPS

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