Trem1 mediates neuronal apoptosis via interaction with SYK after spinal cord ischemia-reperfusion injury.

Wei Shi,Yanqing Sun,Juncheng Wang,Yifan Tang,Shengyuan Zhou,Zheng Xu,Bo Yuan, Xiangwu Geng,Xiongsheng Chen

American journal of translational research（2021）

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摘要

Trem1 interacts with SYK and mediates neuronal apoptosis via the PI3K/AKT and NF-κB signaling pathway. Trem1 may be a therapeutic candidate for patients with SCIRI.

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关键词

NF-κB,PI3K/AKT,SYK,Spinal cord ischemia-reperfusion injury,Trem1,apoptosis

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