2,3-Diphenyl-2,3-dihydro-4H-1,3-thiaza-4-one heterocycles inhibit growth and block completion of cytokinesis in kinetoplastid parasites

Madeline F Malfara,Lee J Silverberg,John DiMaio,Anthony F Lagalante,Mark A Olsen, Ekaterina Madison,Megan L Povelones

Molecular and Biochemical Parasitology（2021）

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摘要

•A series of 1,3-thiaza-4-one heterocycles inhibits growth of Crithidia fasciculata and Trypanosoma brucei.•A pyridothiazinone causes a pre-abscission arrest in the cell cycle of T. brucei.•Pre-abscission-arrested T. brucei cells remain linked by mitochondrial tubules.

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关键词

Trypanosoma brucei,Crithidia fasciculata,Cell cycle,Cytokinesis,Mitochondria,Pyridothiazinone

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