Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell-Depleted Patients

Arvind Gharbharan,Corine H GeurtsvanKessel,Carlijn C E Jordans,Marc Blaauw,Marjolein van der Klift,Robert-Jan Hassing,Marijn Smits-Zwinkels,Maaike Meertens,Ella C van den Hout,Anne Marie de Man, Ilse Hageman,Susanne Bogers,C Ellen van der Schoot,Francis Swaneveld,Adam A Anas,Casper Rokx,Bart J A Rijnders

CLINICAL INFECTIOUS DISEASES（2022）

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摘要

Twenty-five B-cell-depleted patients (24 following anti-CD19/20 therapy) diagnosed with coronavirus disease 2019 had been symptomatic for a median of 26 days but remained antibody negative. All were treated with convalescent plasma with high neutralizing antibody titers. Twenty-one (84%) recovered, indicating the potential therapeutic effects of this therapy in this particular population.

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关键词

COVID, 19, SARS, CoV, 2, immunodeficiency, B, cell depletion, convalescent plasma

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