Evaluation of hydrogen peroxide virucidal efficacy against yellow fever virus 17DD vaccine strain for application in a vaccine manufacturing industry

Journal of Pharmaceutical and Biomedical Analysis(2021)

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摘要
•Exposure to HPL ≥ 10 % for 20 min was efficient for yellow fever virus disinfection.•Exposure to HPV was efficient for disinfection of yellow fever virus in FYV.•Exposure to HPV wasn’t efficient for disinfection of yellow fever virus in API.•Residual H2O2 caused damage to cells and must be removed to before titration.•Presence of organic material and catalase reduced the efficacy of HPV disinfection.
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关键词
Hydrogen peroxide,Cleaning validation,Vaccine,Yellow fever virus,Disinfection,Virus inactivation
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