Human papillomavirus vaccination history and diagnosis of cervical intraepithelial neoplasia grade ≥2 severe lesions among a cohort of women who underwent colposcopy in Kaiser Permanente Southern California

Our study did not support modifying colposcopy management guidelines for abnormal screening results for HPV vaccinated women, especially those vaccinated in the catch-up age range. Our findings on the eight cases of HPV16+ CIN2+ vaccinated prior to sexual debut suggest lowering the recommended age for HPV vaccination may have additional benefits for preventing HPV infection that could occur early in life in some women.