Design and rationale of a clinical trial to increase cardiomyocyte division in infants with tetralogy of Fallot

Samar R El Khoudary,Anthony Fabio,Jessie W Yester,Matthew L Steinhauser,Adam B Christopher,Frank Gyngard,Phillip S Adams,Victor O Morell,Melita Viegas, Jose P Da Silva,Luciana F Da Silva,Mario Castro-Medina,Andrew McCormick,Miguel Reyes-Múgica, Michelle Barlas,Honghai Liu,Dawn Thomas,Niyatie Ammanamanchi, Rachel Sada, Megan Cuda, Elizabeth Hartigan, David K Groscost,Bernhard Kühn

International Journal of Cardiology（2021）

引用 7|浏览7

暂无评分

摘要

•Design of clinical trial to induce heart muscle cell (cardiomyocyte) proliferation in infants with tetralogy of Fallot.•New approach using 15N-thymidine administration to label generated cardiomyocytes.•Multi-isotope Imaging Mass Spectrometry (MIMS) as readout on resected pieces of myocardium.•Positive result could introduce a new concept of increasing cardiomyocyte division with β-blocker administration

查看译文

关键词

Congenital heart disease,Tetralogy of Fallot,Cardiomyocyte division,Beta-blocker,Ventricular hypertrophy

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要