Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

Maria Serra-Blasco,Joaquim Radua,Carles Soriano-Mas, Alba Gómez-Benlloch,Daniel Porta-Casteràs,Marta Carulla-Roig, Anton Albajes-Eizagirre,Danilo Arnone,Paul Klauser, Eric J. Canales-Rodríguez,Kevin Hilbert,Toby Wise,Yuqui Cheng,Sevdalina Kandilarova,David Mataix-Cols, Eduard Vieta,Esther Via,Narcís Cardoner

Neuroscience & Biobehavioral Reviews（2021）

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摘要

•MDD participants have smaller GMV than HC in cerebellum and the frontal operculum.•ANX participants have less GMV than HC in temporal gyrus and pars orbitalis.•PTSD participants have smaller GMV in lingual gyrus and superior frontal gyrus.•As patients age, GMV reductions are more pronounced in fronto-temporal regions.•Higher proportion of females are related with GMV diminutions in temporal areas.

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关键词

Major depressive disorder,Anxiety disorders,Posttraumatic stress disorder,Comorbidities,Gray matter volume,Meta-analysis,Structural neuroimaging,Neuropsychiatry

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