Fisetin promotes osteoblast differentiation and osteogenesis through GSK-3β phosphorylation at Ser9 and consequent β-catenin activation, inhibiting osteoporosis

Fisetin induces glycogen synthase kinase-3β (GSK-3β) phosphorylation and, in turn, promotes the nuclear translocation of β-catenin, which enhances bone formation. Additionally, fisetin prevents prednisolone-induced osteoporosis.