Comprehensive immunomolecular profiling of endometrial carcinoma: A tertiary retrospective study

Jasper Victoor,Sara Vander Borght,Lien Spans,Stefan Lehnert,Hilde Brems,Annouschka Laenen,Ignace Vergote,Toon Van Gorp,Els Van Nieuwenhuysen,Sileny Han,Stefan Timmerman,Anne-Sophie Van Rompuy,Isabelle Vanden Bempt

Gynecologic Oncology（2021）

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摘要

•Comprehensive NGS may help to determine pathogenicity of non-hotspot POLE variants.•Comprehensive NGS can identify targetable alterations in endometrial cancer cases.•POLEmut and MMRd endometrial cancers have higher numbers of TILs and PD-L1-expressing immune cells.•Determination of CD3, CD8 and PD-L1 expression may reveal endometrial cancers benefitting from immune checkpoint inhibition.•p53 abn endometrial cancers have higher L1CAM expression and lack ARID1A or PTEN variants.

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关键词

Endometrial carcinoma,Comprehensive immunomolecular profiling (CIMP),POLE,MMRd,p53,NSMP

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