Stroke Severity in Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement: A Systematic Review and Meta-Analysis

Journal of Stroke and Cerebrovascular Diseases(2021)

引用 5|浏览1
暂无评分
摘要
Objectives: An assessment of the comparative incidence of fatal or disabling stroke may influence choice of intervention for patients with severe aortic stenosis. We explored whether transcatheter aortic valve implantation (TAVI) is associated with a lower inci-dence of fatal or disabling stroke, compared to surgical aortic valve replacement (SAVR). Materials & Methods: We classified stroke into two categories; fatal or disabling, or non-disabling, and completed meta-analyses for each. We explored randomised con -trolled trials to assess the effect publication year, predicted operative risk, and route of TAVI access. Results: There was no difference between treatment groups per 100 person years of follow up for disabling or non-disabling stroke outcomes. Ina stratified analy-sis by year of publication, there was a lower rate of fatal or disabling stroke with TAVI in trials published after 2015, compared to those published in 2015 or before (p-interac-tion = 0.01 at 30 days). Higher proportions of transfemoral route access (>90%), more common in recent trials, were associated with a lower rate of fatal or disabling stroke (p-interaction = 0.03 at 30 days). Lower average surgical risk scores were associated with lower rates of fatal or disabling stroke (p = 0.02 at 30 days). Conclusion: We found that treatment of aortic stenosis with TAVI compared with SAVR was not associated with an overall reduced risk in fatal or disabling stroke. Subgroup analyses suggested a lower risk of fatal or disabling stroke with TAVI in situations which reflect contempo-rary practice.
更多
查看译文
关键词
TAVI,SAVR,Stroke,Stroke severity,Meta-analysis
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要