Aspergillus Flavus Infections In Children With Leukemia Despite Liposomal Amphotericin-B Prophylaxis

Nadja Hawwa Vissing,Birgitte Lausen,Marianne Hutchings Hoffmann,Bodil Als-Nielsen,Kjeld Schmiegelow,Jannik Helweg-Larsen,Maiken Cavling Arendrup,Ulrikka Nygaard

PEDIATRIC INFECTIOUS DISEASE JOURNAL（2021）

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摘要

Liposomal amphotericin-B (L-AmB) prophylaxis is used in children with leukemia when azoles are contraindicated, but its effect is debated. We reviewed cases of invasive aspergillosis despite L-AmB 2.5 mg/kg twice weekly in children with high-risk leukemia during 2012-2019. Ten (16%) of 62 children had proven or probable aspergillosis. Thus, L-AmB prophylaxis offered insufficient protection for Aspergillus, in particular for Aspergillus flavus.

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关键词

pediatric leukemia, invasive fungal disease, Aspergillus flavus, prophylaxis

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