Nrg1 haploinsufficiency alters inhibitory cortical circuits

Carmen Navarro-Gonzalez,Héctor Carceller,Marina Benito Vicente,Irene Serra,Marta Navarrete Llinás, Yaiza Domínguez Canterla,Ángela Rodríguez-Prieto,Ana González-Manteiga,Pietro Fazzari

Neurobiology of Disease（2021）

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摘要

Neuregulin 1 (NRG1) and its receptor ERBB4 are schizophrenia (SZ) risk genes that control the development of both excitatory and inhibitory cortical circuits. Most studies focused on the characterization ErbB4 deficient mice. However, ErbB4 deletion concurrently perturbs the signaling of Nrg1 and Neuregulin 3 (Nrg3), another ligand expressed in the cortex. In addition, NRG1 polymorphisms linked to SZ locate mainly in non-coding regions and they may partially reduce Nrg1 expression.

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关键词

Nrg1,Schizophrenia,Cortical neurons,Inhibitory neurotransmission,Magnetic resonance spectroscopy

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