Inflammatory factors are crucial for the pathogenesis of post-traumatic osteoarthritis confirmed by a novel porcine model: “Idealized” anterior cruciate ligament reconstruction” and gait analysis

•In this study, we used a gait analysis system to prove the biomechanical stability of the idealized anterior cruciate ligament reconstruction model in a mini-pigs for the first time.•Inflammatory factors analysis showed that all tested inflammatory factors showed significantly increased concentrations in the synovial fluid in the IACL-R group after the surgery. It is suggested that significantly elevated inflammatory factors may be a crucial factor in the pathogenesis of PTOA,