RNAseq studies reveal distinct transcriptional response to vitamin A deficiency in small intestine versus colon, uncovering novel vitamin A-regulated genes

Zhi Chai,Yafei Lyu,Qiuyan Chen,Cheng-Hsin Wei,Lindsay M. Snyder,Veronika Weaver,Aswathy Sebastian,István Albert,Qunhua Li,Margherita T. Cantorna,A. Catharine Ross

The Journal of Nutritional Biochemistry（2021）

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摘要

•Mbl2, Cxcl14, and Nr0b2 may be new candidate genes regulated by Vitamin A (VA) in small intestine.•Mast cells and Tuft cells may be targets of VA in small intestine.•Small intestine and colon, although as consecutive organs, were impacted by VA distinctively.•Preexisting VA deficiency may pre-determine the host responses to pathogens.

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关键词

vitamin A deficiency,small intestine,colon,gene expression profile,RNAseq,Weighted Gene Co-expression Network Analysis (WGCNA)

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