SIRT6 inhibits inflammatory response through regulation of NRF2 in vascular endothelial cells
International Immunopharmacology（2021）
摘要
•SIRT6 inhibits TNF-α-induced inflammation depend on its deacetylase activity in endothelial cells.•SIRT6 inhibits inflammation by promoting NRF2 expression in endothelial cells.•SIRT6 inhibits hyperlipidemia-induced vascular inflammation in mice.
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关键词
SIRT6,Inflammation,NRF2,Endothelial cells
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