Angiotensin II type 1 receptor deficiency protects against the impairment of blood-brain barrier in a mouse model of traumatic brain injury.

Lijun Yang,Zeshang Chen,Xiangdong Wan,Minghao Liu,Jianliang Wu,Yan Chen,Gengshen Zhang,Zhenzeng Fan

The International journal of neuroscience（2023）

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摘要

T receptor deficiency attenuated TBI-induced impairments of BBB by rescuing tight junction proteins and inhibited AQP4 polarization, thus improving the function of glymphatic system to enhance interstitial Aβ clearance in TBI mice brain.

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关键词

AQP4,AT1,Aβ,BBB,TBI

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