Sinusoidal Obstruction Syndrome in a Young Woman With Antiphospholipid Syndrome on Oral Contraceptives

Hepatic sinusoidal obstruction syndrome (SOS), historically known as veno-occlusive disease (VOD), is a disorder characterized by a hepatic venous outflow obstruction in the intrahepatic sinusoidal venules. Sequelae includes congestive hepatopathy, portal hypertension, and acute liver failure (1). SOS is traditionally seen in those undergoing chemoradiation therapy prior to hematopoietic stem cell transplantation (HSCT), or in the post-hematopoietic cell transplant setting manifesting as an obliterative venulitis (1).