Sub/supercritical Fluid Chromatography Purification and Desalting of a Cyclic Dinucleotide STING Agonist

Peng Li,Henry Yip,Dawn Sun,James Kempson, Janet Caceres-Cortes,Arvind Mathur,Dauh-Rurng Wu

Journal of Chromatography A（2021）

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摘要

•An “endotoxin-free” purification and desalting of a cyclic dinucleotide (CDN) was achieved.•The purification and desalting were scaled up to produce multigram quantities of pure target.•Water with buffer additive was essential to improving the peak shape and resolution.•High co-solvent percentage was needed to adequately elute the extremely hydrophilic target in both steps.

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关键词

supercritical fluid chromatography,achiral SFC,effect of water,effect of buffer additive,cyclic dinucleotide (CDN),STING

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