FBXW5 aggravates hepatic ischemia/reperfusion injury via promoting phosphorylation of ASK1 in a TRAF6-dependent manner

Ting-Ting Li,Yun-Hai Luo,Hang Yang,Hao Chai,Zi-Lun Lei,Da-Di Peng,Zhong-Jun Wu,Zuo-Tian Huang

International Immunopharmacology（2021）

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摘要

•FBXW5 aggravates hepatic ischemia/reperfusion injury.•FBXW5 facilitates ASK1 phosphorylation.•Joint administration of ASK1 and mTOR shows a better efficacy.

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关键词

FBXW5,Liver ischemia/reperfusion injury,ASK1,TRAF6,Inflammation

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