Clinical Characteristics And Factors Associated With Bone Erosion In Gout Patients With Tophi

Background:Bone erosion is a frequent complication of gout patients with tophi and can lead to joint damage, deformity and musculoskeletal disability. Few studies have focused on clinical characteristics and factors associated with bone erosion in gout patients with tophi.Objectives:The aim of this study was to describe clinical characteristics of bone erosion in gout patients with tophi.Methods:Bone erosion was detected by X-ray. Gout patients with tophi were divided into bone erosion group and non bone erosion group. The clinical characteristics were recorded. Comparison of clinical characteristics and risk factors for bone erosion were analyzed between two groups. Multivariate logistic regression analysis was conducted.Results:A total of 171 gout patients with tophi were enrolled, 121 patients with bone erosion and 50 patients without bone erosion. Bone erosion group were older, with prolonged duration with gout and tophi, higher levels of serum creatinine, lower levels of glomerular filtration rate (GFR), C-reactive protein and BMI. In univariate regression analysis, age, gout duration, tophi duration, GFR were associated with bone erosion. In multivariable logistic regression analysis, tophi duration was independently associated with bone erosion.Conclusion:Gout patients with bone erosion present different clinical characteristics compared with those without bone erosion. Tophi duration was strongly associated with bone erosion in patients with gout.Table 1.Comparison of clinical characteristics between bone erosion patients and non bone erosion patients.Non Bone erosionBone erosionP ValueN(male)50(47)121(118)0.255Age(year)45.82±14.1553.74±14.880.002BMI (kg/m2)26.01±4.5824.18±4.720.027WBC(109/mL)9.73±3.4011.37±13.260.404PLT(109/mL)329.86±96.22328.31±124.020.938HGB(g/L)86.58±63.78102.75±51.160.201ALT(U/L)37.74 ±26.5634.26±35.260.561sUA(umol/L)540.16±121.79539.00±121.460.962sCr(umol/L)111.47±25.26135.77±52.43<0.001GFR(ml/min/1.73m2)74.01±27.9456.68±22.840.003ESR(mm/h)61.78±37.3253.08±36.700.181CRP(mg/L)60.00±58.2636.45±42.620.014Gout duration (year)9.22±5.4612.63±7.590.001Tophi duration(year)3.77±3.226.64±4.810.001Hypertension, n17520.277Diabetes, n9120.143Smoking history, n20550.513Drinking history, n14370.737Ulceration, n10350.228Disclosure of Interests:None declared.