Adjuvant-like biomimetic nanovesicles combat New Delhi metallo-β-lactamases (NDMs) producing superbugs infections

SiXuan Wu,TingTing Yu,RuiXue Zhou,Yan Liang,YaQiong Li,JiaLi Yang,YiFei Wang,JingYi An,ShangShang Qin,ZhenZhong Zhang,JinJin Shi

Nano Today（2021）

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摘要

•PAMAM reverses the carbapenem resistance in NDMs-producing pathogen by unique dual mechanisms.•Biomimetic design aids meropenem-PAMAM complex for precisely targeting of pathogen-induced inflammatory sites in vivo.•PAMAM facilitates the storage of meropenem into nanovesicles and accelerates drugs release in infected tissues.

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关键词

NDMs,Carbapenems,Adjuvant activity,Pathogen-targeting,Inflammatory controlled release

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