Fibroscan (R) Probe Selection For Lean Adults

Background and Aim Fibroscan (R) is used to assess fibrosis and steatosis of the liver noninvasively. The company suggests to use the S+-probe in people <18 years with a thoracic circumference (TC) between 45 and 75 cm and the M+-probe in children with a TC >75 cm and adults with a skin-liver capsule distance <2.5 cm. For lean adults with a TC <= 75 cm, no comparative studies have been performed. Furthermore, it is unclear whether lean adults need to be fasted before assessment.Methods We compared liver stiffness (LS) using Fibroscan (R) S+- and M+-probes and controlled attenuation parameter (CAP; only available for M+-probe) in healthy volunteers with a TC <= 75 cm compared with those with a TC >75 cm in fasting state and after intake of a standardized light meal (300 kcal).Results We examined 50 volunteers (26 female, 24 +/- 3 years). Twenty-two participants were in the TC <= 75 cm group and 28 in TC >75 cm group. LS values with the S+-probe were 15% higher than with the M+-probe in both groups (median difference 0.6 kPa, P < 0.001). Both probes showed good agreement with minimal bias (Spearman correlation r = 0.754, P < 0.001; Interclass Correlation Coefficient 0.843, P < 0.001; Bland-Altman bias 0.6 +/- 0.9 kPa, linear regression r(2) = 0.557, P < 0.001). Intake of a light meal had no relevant influence on LS (S+- and M+-probes) or CAP measurements (M+-probe) in both groups.Conclusion Lean adults with a TC below 75 cm can be assessed with either the S+-probe or the M+-probe and may take a light meal before assessment.