Synthesis, structure and characterization of a novel decavanadate, Mg(H2O)6(C4N2H7)4V10O28.4H2O, with a potential antitumor activity

Abstract A novel decavanadate compound, Mg(H2O)6(C4N2H7)4V10O28.4H2O, was synthesized by slow evaporation at room temperature and characterized through single crystal X-ray diffraction, SEM-EDX, IR spectroscopy. The compound crystallizes in a monoclinic system, P21/n space group with a=10.661(5) A, b=21.256(9) A, c=10.767(5) A, β=102.82(4), Z=2 and a volume of 2379.13(2) A3. The compound structure consists of centrosymmetric decavanadate groups, Mg(H2O)6 polyhedral, (C4N2H7)+ cations and water molecules linked through N-H...O and O-H...O hydrogen bonds. The three-dimensional Hirshfeldsurface (3D-HS) and the relative two-dimensional fingerprint plots (2D-FP) revealed that the structure is dominated by H…O/O…H and H…H interactions. When injected to mice by intraperitoneal route, Mg(H2O)6(C4N2H7)4V10O28.4H2O showed toxicity only at a high dose (5mg/kg), as revealed by clinical and biochemical results, as well as histological examination of mice\u0027s liver and kidney. Interestingly, the synthetic compound inhibited the growth of three invasive cancer cell lines; U87 (glioblastoma), IGR39 (melanoma) and MDA-MB-231(triple negative breast cancer) by a dose dependent manner with an IC50 values of 2 µM for both U87 and MDA-MB-231 cells and 3 µM for IGR39 cells. Therefore, we could consider that Mg(H2O)6(C4N2H7)4V10O28.4H2O opens up a window toward the conception of potential organo-metalic dugs with antitumoral properties.