Sprinkling Salt On Mitochondria: The Metabolic And Pathophysiological Roles Of Mitochondrial Na+ Signaling Mediated By Nclx

CELL CALCIUM（2021）

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摘要

NCLX, the mitochondrial Na+/Ca2+ transporter is a key player in Ca2+ signaling. However, its role in Na+ signaling is poorly understood. In this review we focus on Na+ signaling by NCLX, and discuss recent physiological and pathophysiological roles attributed to the Na+ influx into mitochondria.

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关键词

NCLX, Mitochondrial Ca2+ efflux, Na+ signaling, Hypoxia, Ischemia

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