An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study

Cristina Vals-Delgado,Juan F. Alcala-Diaz,Helena Molina-Abril,Irene Roncero-Ramos,Martien P.M. Caspers,Frank H.J. Schuren,Tim J. Van den Broek, Raul Luque,Pablo Perez-Martinez,Niki Katsiki,Javier Delgado-Lista,Jose M. Ordovas,Ben van Ommen,Antonio Camargo,Jose Lopez-Miranda

Journal of Advanced Research（2022）

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摘要

•Type 2 diabetes (T2DM) increases the risk of recurrence in myocardial infarction patients.•A gut microbiota profile is associated to the further T2DM development.•Microbiome data improved the prediction of T2DM development when added to clinical parameters.•A risk score including the most predictive genera was associated with the probability of T2DM.•A high risk score was associated with a higher hepatic insulin resistance and β-cell dysfunction.

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关键词

Intestinal microbiota,Type 2 diabetes mellitus,Predictive model,Coronary heart disease,CORDIOPREV

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