Tetrahydrobiopterin shifts the balance from oxidative stress to NO signalling in Duchenne muscular dystrophy

In this issue, Lindsay et al., 2021 investigated if patients with Duchenne muscular dystrophy (DMD) had reduced levels of the anti-oxidant and arginine-NO coupling cofactor Tetrahydrobiopterin (BH4) and determined if supplementation with BH4 reduced DMD disease progression in the mdx mouse model of DMD.