Real-World Data Of Subcutaneous Trastuzumab And Intravenous Pertuzumab As Neoadjuvant Therapy For Localized Her2+ Breast Cancer In Panama
BREAST CANCER MANAGEMENT(2021)
摘要
The aim of this study is to determine the effectiveness of subcutaneous trastuzumab in combination with intravenous pertuzumab and chemotherapy for patients with HER2-overexpressing localized breast cancer treated in our center. Methods: This was a descriptive, retrospective, real-world study. Results: Of 156 patients, pathological complete response (pCR) was achieved in 64.1%. A multivariate analysis showed a relationship with a negative hormone receptor (HR) expression and a HER2 score of 3+ by immunohistochemistry. Relapse-free survival (RFS) was higher in patients with pCR. Conclusion: Neoadjuvant therapy with dual blockade using intravenous pertuzumab and subcutaneous trastuzumab for HER2+ localized breast cancer in routine clinical practice resulted in a 64.1% pCR rate. Additionally, this outcome was related to a negative HR expression and HER2 overexpression, and correlated with higher relapse-free survival.
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关键词
anthracyclines, breast cancer, disease-free survival, effectiveness, neoadjuvant therapy, pathological complete response, pertuzumab, real-world data, toxicity, trastuzumab
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