Rolling-circle and strand-displacement mechanisms for non-enzymatic RNA replication at the time of the origin of life

Journal of Theoretical Biology（2021）

引用 18|浏览5

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摘要

•Non-enzymatic replication may have preceded ribozyme-catalyzed replication in the RNA World.•Reannealing inhibits replication driven by temperature cycling at low concentrations.•Strand-displacement mechanisms are not inhibited by reannealing.•Rolling circle replication is the most likely first mechanism in the RNA World.

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关键词

Origin of Life,RNA World,Non-enzymatic template-directed replication,Strand-displacement,Rolling circle

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