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The C-terminal Fragment of LRRK2 with the G2019S Substitution Increases the Neurotoxicity of Mutant A53T Α-Synuclein in Dopaminergic Neurons in Vivo

Noemie Cresto,Camille Gardier,Marie-Claude Gaillard,Francesco Gubinelli,Pauline Roost,Daniela Molina,Charlene Josephine,Noelle Dufour,Gwenaelle Auregan,Martine Guillermier,Sueva Bernier,Caroline Jan,Pauline Gipchtein,Philippe Hantraye,Marie-Christine Chartier-Harlin,Gilles Bonvento,Nadja Van Camp,Jean-Marc Taymans,Karine Cambon,Geraldine Liot,Alexis-Pierre Bemelmans,Emmanuel Brouillet

International Journal of Molecular Sciences（2021）

Cited 8|Views49
Key words
Parkinson’s disease,leucine-rich repeat kinase 2,α-synuclein,AAVs,cell-autonomous mechanisms
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