Biomechanical-Structural Correlation Of Chordae Tendineae In Animal Models: A Pilot Study

Simple Summary The Chordae tendineae are part of the atrioventricular apparatus. They are mainly responsible for the mechanical functions of heart valves. Degenerative mitral valve disease is the most common heart disease in dogs and is responsible for about 75% of cases of heart failure. One of the complications of this disease is Chordae tendineae rupture. It is clinically relevant to better understand the biomechanical and structural properties of CT in order to begin further studies about biomarkers suggesting an episode of CT rupture. Such an episode leads to acute pulmonary oedema and worsens the clinical status of the patient. Information about the biomechanical and structural properties of healthy CT and CT affected by the degenerative process are essential in understanding how CT behave in an in vivo environment. The mitral valve apparatus is a complex structure consisting of the mitral ring, valve leaflets, papillary muscles and Chordae tendineae (CT). The latter are mainly responsible for the mechanical functions of the valve. Our study included investigations of the biomechanical and structural properties of CT collected from canine and porcine hearts, as there are no studies about these properties of canine CT. We performed a static uniaxial tensile test on CT samples and a histopathological analysis in order to examine their microstructure. The results were analyzed to clarify whether the changes in mechanical persistence of Chordae tendineae are combined with the alterations in their structure. This study offers clinical insight for future research, allowing for an understanding of the process of Chordae tendineae rupture that happens during degenerative mitral valve disease-the most common heart disease in dogs.