High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells

Tiara Bunga Mayang Permata,Hiro Sato,Wenchao Gu,Sangeeta Kakoti,Yuki Uchihara, Yukihiko Yoshimatsu, Itaru Sato,Reona Kato,Motohiro Yamauchi,Keiji Suzuki,Takahiro Oike,Yoshito Tsushima,Soehartati Gondhowiardjo,Tatsuya Ohno,Takaaki Yasuhara,Atsushi Shibata

Journal of Radiation Research（2021）

引用 17|浏览5

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摘要

Programmed death ligand 1 (PD-L1) expression on the surface of cancer cells affects the efficacy of anti-PD-1/PD-L1 immune checkpoint therapy. However, the mechanism underlying PD-L1 expression in cancer cells is not fully understood, particularly after ionizing radiation (IR). Here, we examined the impact of high linear energy transfer (LET) carbon-ion irradiation on the expression of PD-L1 in hu...

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关键词

anti-PD-1/PD-L1 therapy,high linear energy transfer (LET) carbon-ion therapy,PD-L1 expression,DNA damage response

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