The Copper-Catalyzed Synthesis Of Dihydrooxazoles From Alpha,Beta-Unsaturated Ketoximes And Activated Ketones

The first copper-catalyzed [3+2]-type condensation reaction of alpha,beta-unsaturated ketoximes with activated ketones has been described for the synthesis of dihydrooxazoles, especially trifluoromethyl-decorated dihydrooxazoles. Notable features of this method include its broad substrate scope, good functional group tolerance, and simple operation.