Impact of Anti-HER2 Treatments Combined With Atezolizumab on the Tumor Immune Microenvironment in Early or Metastatic Breast Cancer: Results From a Phase Ib Study

Erika P. Hamilton,Virginia Kaklamani,Carla Falkson,Gregory A. Vidal,Patrick J. Ward,Monika Patre,Stephen Y. Chui,Jacob Rotmensch,Kushagra Gupta,Luciana Molinero,Yijin Li,Leisha A. Emens

Clinical Breast Cancer（2021）

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摘要

•Anti–PD-L1 plus anti-HER2 treatment changes tumor immunity in early breast cancer.•Metastatic HER2+ breast cancer shows changes only in tumor immune PD-L1 expression.

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关键词

Immunotherapy,Trastuzumab,Pertuzumab,T-DM1,Trastuzumab emtansine

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