Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway

Bei Ren,Jinping Feng,Ning Yang, Yujun Guo,Cheng Chen,Qin Qin

International Immunopharmacology（2021）

引用 36|浏览2

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摘要

•Ginsenoside Rg3 weakened AngⅡ-induced myocardial hypertrophy and fibrosis.•Rg3 inhibited the levels of NLRP3 inflammasome and oxidative stress in cardiomyocytes.•Rg3 regulated the SIRT1/NF-κB signaling pathway.•Rg3 attenuated the progression of myocardial hypertrophy in vivo.

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关键词

Ginsenoside Rg3,Angiotensin II,Myocardial hypertrophy,NLRP3,Oxidative stress

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