Computer-assisted UHPLC method development and optimization for the determination of albendazole and its related substances

•Computer aided chromatographic method development for the simultaneous determination of albendazole and its related substances.•Optimization was realized using experimental design-based approach.•Alternative to replace an underperforming European Pharmacopoeia method.•In silico robustness testing and retention modelling performed by DryLab software.•After validation, method applicability was tested on commercial tablet formulation.