Dynamics of MHC-I molecules in the antigen processing and presentation pathway
Current Opinion in Immunology（2021）
摘要
•MHC-I molecules exhibit allotype-dependent conformational flexibility, which is critical for their function.•Peptide-deficient MHC-I adopt distinct groove conformations, relevant for peptide binding.•Molecular chaperones locally and allosterically modulate dynamics to edit the peptide repertoire.
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