Induction of Neurogenesis and Angiogenesis in a Rat Hemisection Spinal Cord Injury Model With Combined Neural Stem Cell, Endothelial Progenitor Cell, and Biomimetic Hydrogel Matrix Therapy.

Eric J Marrotte, Khari Johnson,Ryan M Schweller,Rachel Chapla,Brian E Mace,Daniel T Laskowitz,Jennifer L West

Critical care explorations（2021）

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摘要

This study demonstrates proof of concept that multimodal therapy with endothelial progenitor cells and neural stem cells combined with a bioactive biomimetic hydrogel can be used to induce de novo CNS tissue in an injured rat spinal cord.

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关键词

angiogenesis,biomedical engineering,biomimetic extracellular matrix,endothelial progenitor cells,hydrogel,neural stem cells,neurogenesis,polyethylene glycol,regenerative medicine,spinal cord injury

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