Novel Long Non-Coding Rna Expression Profile Of Peripheral Blood Monouclear Cell Revealed Potential Biomarkers And Regulatory Mechanism In Systemic Lupus Erythematosus

In this work, we identified many mRNAs and novel lncRNAs by transcriptome sequencing. The functions and regulatory mechanisms of these lncRNAs were analyzed by bioinformatic methods. The novel lncRNA is significantly downregulated in SLE patients and is significantly related to the activity and severity of disease. Additionally, we propose that may enhance the signal transduction of β2-AR by cis regulating , inducing NK cells to produce high levels of IFN-γ and thereby exacerbating SLE.