Establishment And Characterization Of A Her2-Positive Cell Line Derived From The Pleural Effusion Of A Drug-Resistant Breast Cancer Patient
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY(2021)
摘要
Drug resistance is a daunting challenge in the treatment of breast cancer, making it an urgent problem to solve in studies. Cell lines are important tools in basic and preclinical studies; however, few breast cell lines from drug-resistant patients are available. Herein, we established a novel HER2-positive breast cancer cell line from the pleural effusion of a drug-resistant metastatic breast cancer patient. This cell line has potent proliferative capability and tumorigenicity in nude mice but weak invasive and colony-forming capability. The molecular subtype of the cell line and its sensitivity to chemotherapeutics and HER2-targeting agents are different from those of its origin, suggesting that the phenotype changes between the primary and metastatic forms of breast cancer.
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关键词
breast cancer cell line 4Z-B-1, HER2-positive, invasive ductal breast carcinoma, metastatic, HER2 targeting, phenotype change
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