p38 inhibition enhances TCR-T cell function and antagonizes the immunosuppressive activity of TGF-β

Siyin Chen,Jing Zhang,Meiying Shen,Xiaojian Han,Shenglong Li,Chao Hu,Wang Wang,Luo Li,Li Du,Da Pang,Kun Tao,Aishun Jin

International Immunopharmacology（2021）

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摘要

•p38 inhibitor promotes the expression of CD62L on CD8+ less differentiated T cell.•P38 inhibitor antagonizes the TGF-β-induced cytokines decreasing.•p38 inhibition could promotes a global gene profile change directly associated with T cell functional improvement.

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关键词

P38 inhibitor,Adoptive cell therapy,Less differentiated T cells,TGF-β,Cytokines

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