Intracranial myeloid sarcoma presentation in distant acute myeloid leukemia remission

•Intracranial myeloid sarcoma is a rare central nervous system manifestation of hematopoietic neoplasms of myeloid origin.•Intracranial myeloid sarcoma most commonly presents in association with acute myeloid leukemia.•Goals of neurosurgical intervention should be symptomatic relief of mass effect and pathological diagnosis.•Intracranial myeloid sarcoma is exquisitely sensitive to adjuvant radiation and medical management.