Burkitt Lymphoma/Leukemia Presented on Ga-68-Pentixafor and F-18-FDG PET/CT

An 18-year-old man with newly diagnosed Burkitt lymphoma/leukemia was referred for F-18-FDG and Ga-68-Pentixafor PET/CT. Ga-68-Pentixafor PET/CT revealed similar radioactivity uptake pattern to the F-18-FDG PET/CT in superior phrenic lymph node, ascending colon, ileocecum, peritoneal, marrow, and spleen. This case highlighted that it might be interesting to further investigate the role of Ga-68-Pentixafor PET/CT imaging in staging, treatment evaluation, and especially the feasibility of CXCR4-directed radioligand therapy in Burkitt lymphoma with positive expression of CXCR4.