Elucidating Prostate Cancer Behaviour During Treatment via Low-pass Whole-genome Sequencing of Circulating Tumour DNA

European Urology（2021）

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摘要

Tumour fraction, independent from cell-free DNA concentration and other clinical variables, is prognostic, with low-pass whole-genome sequencing profiles detecting abiraterone/enzalutamide-induced emerging genomic instability that is likely to be acquired as a result of tumour development.

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关键词

Metastatic castration-resistant prostate cancer,mCRPC,Low-pass whole-genome sequencing,lpWGS,Cell-free DNA,cfDNA,ctDNA,Tumour fraction,Taxanes,Cabazitaxel

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