Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model

Kyle A. Brown,Jessica M. Carpenter, Collin J. Preston, Helaina D. Ludwig,Kendall B. Clay,Donald A. Harn,Thomas Norberg,John J. Wagner,Nikolay M. Filipov

Life Sciences（2021）

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摘要

•GWI-related exposures induced a biphasic effect on basal synaptic transmission.•Progressively worsened impairments in hippocampal LTP were found in GWI animals.•Synaptic deficits were more pronounced in the dH than the vH in GWI animals.•Coadministered LNFPIII enhanced synaptic plasticity and transmission.•Delayed LNFPIII treatment ameliorated GWI deficits 11 months post-exposure.

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ACSF,BDNF,CNTF,DEET,DFP,dH,ERK-1/2,fEPSP,GWI,GWIR,GWV,IL-6,IL-1β,LNFPIII,LTP,NGF,PB,PPF,SYP,TNFα,vH

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